The 3rd International Symposium on Multi-disciplinary Computational Anatomy

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The 3rd International Symposium on Multi-disciplinary Computational Anatomy

Name of symposium

  • Official name
    • The 3rd International Symposium for Scientific Research on Innovative Areas "Multidisciplinary Computational Anatomy and Its Application to Highly Intelligent Diagnosis and Therapy"
  • Abbrev. name
    • The 3rd International Symposium on Multidisciplinary Computational Anatomy


  • March 8 and 9, 2017


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  • Nara Prefectural Cultural Center, Nara Japan

Invited talk

  • Simon K. Warfield
  • Department of Radiology, Boston Children’s Hospital, Harvard Medical School, Boston, USA
  • Title : Computational Pediatric Imaging and Simulations
  • Abstract
    Advances in pediatric medical imaging have created unprecedented new capabilities to probe the mechanisms that underlie pediatric disease and disorders of development. Innovative MRI techniques hold out the promise of enhancing the detection and characterization of disease, and of facilitating new interventions for the treatment of disease. In our recent work, we have focused on the development of imaging biomarkers of autism spectrum disorder and epilepsy, with a view to enabling early intervention. New computational strategies have allowed us to image pediatric subjects with high spatial resolution, to compensate for motion during imaging, and to reveal new tissue microstructure. Patient specific simulation has enabled the characterization of atypical electrical activity. The further development of these quantitative pediatric neuroimaging capabilities holds out the promise of enabling early prediction of children at risk of adverse long-term outcomes. Imaging and simulation have a critical role to play in rapidly assessing the efficacy of potential therapeutic interventions, and in tailoring treatment to individuals where it can be most effective.
  • Denis Le Bihan
  • NeuroSpin, CEA-Saclay Center, Gif-sur-Yvette, France
  • Title : Investigating brain anatomy and function with diffusion MRI
  • Abstract
    In the mid 1980s it was shown that water diffusion in the brain could be imaged using Magnetic Resonance Imaging (MRI). During their random displacements water molecules probe tissue structure at a microscopic scale, thus providing unique information on the functional architecture of tissues. A dramatic application of diffusion MRI has been acute brain ischemia, following the discovery that water diffusion drops immediately after the onset of an ischemic event, when brain cells undergo swelling through cytotoxic edema. With its unmatched sensitivity water diffusion MRI provides patients with the opportunity to receive suitable treatment at a stage when brain tissue might still be salvageable, thus avoiding them terrible handicaps. On the other hand, it was found that water diffusion is anisotropic in white matter, because axon membranes limit molecular movement perpendicularly to the fibers. This feature can be exploited to produce stunning maps of the orientation in space of the white matter tracks and brain connections in just a few minutes, as well as to provide information on white track microstructure and integrity. With water diffusion MRI it has been shown that some psychiatric disorders, such as schizophrenia might result from faulty brain connection. Diffusion MRI has also the potential to give clues on the cellular organization within brain cortex on an individual basis, a step forward to segregating brain areas at mesoscale level, which could reveal a neural code, as there is a genetic code. More recently, it has been shown that diffusion MRI could even be used to detect brain activation. Functional neuroimaging has emerged as an important approach to study the brain and the mind. Surprisingly, although they are based on radically different physical approaches both positron emission tomography (PET) and MRI make brain activation imaging possible through measurements involving water molecules. So far, PET and MRI functional imaging have relied on the principle that neuronal activation and blood flow are coupled through metabolism. However, a new paradigm has emerged to look at brain activity through the observation with MRI of the molecular diffusion of water. In contrast with the former approaches diffusion MRI has the potential to reveal changes in the intrinsic water physical properties during brain activation, which could be more intimately linked to the neuronal activation mechanisms and lead to an improved spatial and temporal resolution. Recent data on the physical properties of water and on the status of water in biological tissues, suggest that the biophysical mechanisms of brain activation have to be reassessed to reveal their intimacy with the physical properties of water, which could, some day, be regarded as the ‘molecule of the mind’?


Day 1 Wedanesday, Mar 8, 9:30 - 17:30(Registration opens at 9:10)Poster set-up(9:00 - 13:30)

  1. Opening remarks/Makoto Hashizume (Kyushu University) (9:30 - 9:35)
  2. Academic specialist's address/Yoshiharu Ishikawa (Nagoya University) (9:35 - 9:45)
  3. Keynote address/Makoto Hashizume (Kyushu University) (9:45 - 10:00)
  4. Invited Talk: Computational Pediatric Imaging and Simulations, Prof. Simon K.Warfield (Harvard Medical School, USA)(10:00 - 11:00)(Session Cahir: Yoshinobu Sato, Nara Institute of Science and Technology)
    Coffee Break (11:00 - 11:15)
  5. Featured Topics by Planned Research Groups A01: Foundations of Multidisciplinary Computational Anatomy (11:15 - 12:15, 3 talks, 20 min each)(Session Cahir: Shoji Kido , Yamaguchi University)
    • (A01-1): Construction of Multi-scale Spatiotemporal Model of Pancreas Cancer from Pathology Images and Time Series of MR Images, Hidekata Hontani (Nagoya Institute of Technology)
    • (A01-2): Spatiotemporal Statistical Model During Human Embryonic Period, Akinobu Shimizu (Tokyo University of Agriculture and Technology)
    • (A01-3): Computational Modeling of Musculoskeletal Functional Anatomy,Yoshito Otake (Nara Institute of Science and Technology)
    Lunch(12:15 - 13:30)
  6. Research Activity Reports by Research Groups A01: Foundations of Multidisciplinary Computational Anatomy (13:30 - 15:00)(Session Chair: Etsuko Kobayashi, The University of Tokyo)
    Poster Teasers by Planned Research Groups (13:45 - 14:00)(3 tearsers, 4 min each)
    • A01-1 Mathematical Foundations of Multidisciplinary Computational Anatomy - Progress Overview FY2016 - (PI Hidekata Hontani)
    • A01-2 Fundamental Technologies for Integration of Multiscale Spatiotemporal Morphology in Multidisciplinary Computational Anatomy - Progress Overview FY2016 - (PI Akinobu Shimizu)
    • A01-3 Fundamental Technologies for Integration of Function and Pathology in Multidisciplinary Computational Anatomy - Progress Overview FY2016 - (PI Yoshinobu Sato)
    Poster Teasers by Public Offered Research Groups(13:45 - 14:00)(7 teasers, 2 min each)
    • A01-KB001 Development of High Resolution Viscoelasti Imaging System using MRI -Progress Overview FY 2016- (PI: Mikio Suga)
    • A01-KB002 Registration between Pathological and MR Images using Optical Macro and Blocked Macro images - Progress Overview FY2016 - (PI Takashi Ohnishi)
    • A01-KB003 Development of fully automatic algorithm for defining anatomical landmarks from a huge image dataset - Progress Overview FY2016 - (PI Shouhei Hanaoka)
    • A01-KB004 Three-dimensional Analysis of the Bronchial Branching in Human Embryonic Stages - Progress Overview FY2016 - (PI Tetsuya Takakuwa)
    • A01-KB005 Feature Extraction of Lung Cancer Pathological Images Using Convolutional Autoencoder -Progress Overview FY 2016- (PI Naoaki Ono)
    • A01-KB006 Design Analysis of Three-Dimensional Periodic Network Patterns of the Sinusoid and Bile Canaliculi in the Hepatic Lobule -Progress Overview FY 2016- (PI Hiroto Shoji)
    • A01-KB007 Spatio-temporal Statistical Shape Model Construction for Longitudinal Brain Deformation Analysis Using Weighted PCA - Progress Overview FY2015 - (PI Syoji Kobashi)
    • A01-KB008 Multi-dimensional Medical Image Analysis Based on Multilinear Spase Coding -Progress Overview FY 2016- (PI Yen-wei Chen)
  7. Poster Session & Coffee Break(14:00 - 15:00)
  8. Featured Topics by Planned Research Groups A02: Computer-aided Diagnosis and Surgery Systems Based on Multidisciplinary Computational Anatomy (15:00 - 16:00, 3 talks, 20 min each)(Session Chair: Hidekata Hontani, Nagoya Institute of Technology)
    • (A02-1): Multi-scale Image Registration for Multi-Modality Lung Cancer Imaging, Holger R. Roth (Nagoya University)
    • (A02-2): SRμCT Imaging of Micro-architecture in the Human Secondary Pulmonary Lobule ,Yoshiki Kawata (Tokushima University)
    • (A02-3): Construction of Carbohydrate Metabolism Model Based on Data-driven Organ Segmentation in PET/CT Images, Takeshi Hara, Xiangrong Zhou (Gifu University)
  9. Research Activity Reports by Research Groups A02: Computer-Aided Diagnosis and Surgery Systems Based on Multidisciplinary Computational Anatomy (16:00 - 17:30)(Session Chair: Akinobu Shimizu, Tokyo University of Agriculture and Technology)
    Poster Teasers by Planned Research Groups(16:00 - 16:15)(3 teasers, 4 min each)
    • A02-1 Pre/intra-operative Diagnostic and Navigational Assistance Based on Multidisciplinary Computational Anatomy - Progress Overview FY2016 -(PI Kensaku Mori)
    • A02-2 Cancer Diagnosis and Prognosis Assistance Based on Multidisciplinary Computational Anatomy - Progress Overview FY2016 - (PI Noboru Niki)
    • A02-3 Function Integrated Diagnostic Assistance Based on Multidisciplinary Computational Anatomy - Progress Overview FY2016 - (PI Hiroshi Fujita)
    Poster Teasers by Public Offered Research Groups(16:15 - 16:35)(9 teasers, 2 min each)
    • A02-KB001 Development of High-Accuracy Brain MRI Image Analysis Techniques Using Brain Local Features - Progress Overview FY2016 - (PI Koichi Ito)
    • A02-KB002 Quantitative Tumor Imaging Technology Assisting 5-ALA-based Neurosurgery - Progress Overview FY2016 - (PI Hideaki Haneishi)
    • A02-KB003 Computerized Evaluation of the Rib Kinetics and Pulmonary Function based on Dynamic Chest Radiography - Progress Overview FY2016 - (PI Rie Tanaka)
    • A02-KB004 Visible to Near-Infrared Spectroscopic Ultrahigh Resolution Optical Coherence Tomography - Progress Overview FY2016 - (PI Norihiko Nishizawa)
    • A02-KB005 Personalized Brain Stimulation with Development of Transcranial Magnetic Stimulation System and Support Software Based on Electromagnetics - Progress Overview FY2016 - (PI Akimasa Hirata)
    • A02-KB006 Computer-Aided Diagnosis System Using Image Features and Metabolic Function for Lesion on Breast MRI - Progress Overview FY2016 - (PI Ryohei Nakayama)
    • A02-KB007 Development of Quantitative Viscoelasticity Imaging Based on Shear Wave Propagation Model and its Application to Diagnosis of Liver Fibrosis - Progress Overview FY2016 - (PI Tsuyoshi Shiina)
    • A02-KB008 X-ray Dark-Field Imaging: Attempts at Improving Spatial Resolution and Medical Applications -Progress Overview FY 2016- (PI Masami Ando)
    • A02-KB009 Development of Diagnostic Algorithms for Dementia Unifying Time Histories of Amyloid Beta, Brain Morphology, and Blood Contents - Progress Overview FY2016 - (PI: Yuichi Kimura)
  10. Poster Session(16:35 - 17:30)

Day 2 Thursday, Mar 9 9:30 - 16:55 (Registration opens at 9:10)

  1. Invited Talk: Investigating Brain Anatomy and Function with Diffusion MRI,Denis Le Bihan (Neuro Spin, France)(9:30 -10:30)(Sssion Chair:Yoshitaka Masutani, Hiroshima University)
    Coffee Break (10:30 - 10:45)
  2. Featured Topics by Planned Research Groups A03: Clinical and Scientific Applications of Multidisciplinary Computational Anatomy (10:45 - 11:45, 3 talks ,20 min each)(Session Chair: Kensaku Mori, Nagoya University)
    • (A03-1): Pathological Digital Date Accumulation of Pancreatic Cancer and its Application to Multidisciplinary Computational Anatomy, Chika Iwamoto (Kyushu University)
    • (A03-2): An Unsupervised Classification Model of Lung Diseases, Shingo Mabu (Yamaguchi University)
    • (A03-3): Augmented Reality Surgical Navigation for Oral and maxillofacialSurgery, Junchen Wang (Beihang University and University of Tokyo)
    Lunch(11:45 - 13:00)
  3. Research Activity Reports by Research Groups A03: Clinical and Scientific Applications of Multidisciplinary Computational Anatomy (13:00 - 14:40)(Session Chair: Noboru Niki,Tokushima University)
    Poster teasers by Planned Research Groups(13:00 - 13:15)(3 teasers, 4 min each)
    • A03-1 Clinical Applications of Multidisciplinary Computational Anatomy to Surgery - Progress Overview FY2016 - (PI Makoto Hashizume)
    • A03-2 Clinical Applications of Multidisciplinary Computational Anatomy to Diagnosis - Progress Overview FY2016 - (PI Shoji Kido)
    • A03-3 Applications of Multidisciplinary Computational Anatomy across Biomedical Engineering - Progress Overview FY2016 - (PI Etsuko Kobayashi)
    Poster Teasers by Public Offered Research Groups (13:15 -13:45)(14 teasers, 2 min each)
    • A03-KB001 Prediction of the Initiation of Cerebral Aneurysms - Progress Overview FY2016 - (PI Kuniyasu Niizuma)
    • A03-KB002 3D Virtual Pancreatic Surgical Simulation Combined with Real-time Deformation using CT-MRI fusion - Progress Overview FY2016 - (PI Yukio Oshiro)
    • A03-KB003 Qualitative Rapid Cell Diagnosis by Mutual Understanding of Acoustic Characteristics and Structural Features of Living Tissue -Progress Overview FY 2016- (PI Tadashi Yamaguchi)
    • A03-KB006 Ischemic Reperfusion Injury by Selective Hepatic Artery Clamping Induced the Sinusoidal Flow Increase in Rat -Progress Overview FY 2016- (PI Atsushi Kudo)
    • A03-KB007 Evaluation of Interstitial Pneumonia using 3D-curved High-resolution CT Imaging Parallel to the Chest Wall - Progress Overview FY2016 - (PI Shingo Iwano)
    • A03-KB008 Micro-Computed Tomography of the Lung: Imaging of Alveolar Duct and Alveolus in Human Lung -Progress Overview FY 2016- (PI Shota Nakamura)
    • A03-KB009 Three-Dimensional Reconstruction from Serial Section of Human Embryos and Application to Education of Developmental Biology - Progress Overview FY2016 - (PI Shigehito Yamada)
    • A03-KB010 Integration of Computed Anatomy and Bio-Texture Modeling Technology for High-intelligence therapeutic navigation system - Progress Overview FY2016 - (PI Maki Sugimoto)
    • A03-KB011 Real-time Measurement of Spinal Canal Deformation from X-Ray Images for a Diagnosis for Lumbar Spinal Stenosis - Progress Overview FY2016 - (PI Amar Husejic)
    • A03-KB012 Enteric Nervous System Visualization with Cresyl Violet-assisted Confocal Laser Endomicroscopy -Progress Overview FT2016 – (PI Kazuki Sumiyama)
    • A03-KB013 Digitized Brain-mapping Localization and their Compiled Brain-function Database For the Future-predicting Glioma Surgery -Progress Overview FY2016 - (PI Manabu Tamura)
    • A03-KB014 Construction of Computational Cardiac Model with Congenital Heart Diseases based on Isolated Human Hearts -Progress Overview FY2016 - (PI Ryo Haraguchi)
  4. Poster Session & Coffee Break (13:45 - 14:40)
  5. Panel Discussion on Goals,Stories, and Scientific Principles of Multidisciplinary Computational Anatomy (14:40 - 15:50)(Session Chairs: Makoto Hashizume, Kyushu University & Hiroshi Fujita, Gifu University)
  6. Activity Reports of Working Groups (15:50 - 16:20) (Session Chair : Hiroshi Fujita, Gifu University)
    Working groups for Public relations, International partnership, Human resources, Scientific principle development, Database assistance, Medical assistance
  7. Final Evaluation of the Project by Advisory Committee Members Session (16:20 - 16:50)(Session Chair Makoto Hashizume, Kyushu University)
  8. Closing remarks/Makoto Hashizume (Kyushu University) (16:50 - 16:55)


  • Date
    • March 8, 2017 18:30 - 20:30
  • Place
    • 葉風泰夢(奈良国立博物館 B1)
  • Admission for reception
    • 5000 JPY per person