A03-KB104 The Morphometric Analysis for the Morphogenesis of the Craniofacial structures and the Evolution of the Nasal Protrusion in Humans

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Member

  • Primary Investigator
    Shigehito Yamada (Kyoto University, Professor)
  • Co-Researcher
    Haruyuki Makishima (Kyoto University, Postdoctoral Fellow)

Overview

Based on observations of human development, it is noted that the shape of craniofacial structures drastically changes between the embryonic and the early fetal period; therefore, this period must be considered the most important period for elucidating the pathogenesis of congenital craniofacial anomalies. The mechanisms to explain these phenomena have remained unclear, because it has been difficult to obtain imaging data required to accurately analyze shape changes. However, recent developments in medical imaging modalities, e.g., magnetic resonance imaging (MRI) and/or computed tomography (CT), have allowed us to study these small specimens in detail. In this study, we aim to elucidate the morphogenesis of craniofacial structures in humans using imaging data. Additionally, we aim to perform an allometric analysis of the brain in this period. These analyses would make it possible to study ontogenetic allometry of these structures in a three-dimensional, e.g., spatio-temporal, statistical model, which could contribute not only to research in areas pertaining to development of the face, but would also be an educational model/tool for medical students. Furthermore, this model could improve our understanding of the association between congenital craniofacial anomalies and mental retardation and facilitate diagnosis of craniofacial anomalies in the early prenatal period.

Project Design

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