A02-KB108 Quantitative Evaluation of Fatty Metamorphosis and Fibrosis of Liver Based on Models of Ultrasound and Light Propagation and its Application to Hepatic Disease Diagnosis

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  • Primary Investigator
    Tsuyoshi Shiina (Kyoto University, Professor)
  • Corporative Researcher
    Makoto Yamakawa (Graduate School of Medicine, Kyoto University, Associate Professor)
    Kengo Kondou (Graduate School of Medicine, Kyoto University, Assistant Professor)
    Masatoshi Kudo (Dept. of Gastroenterology and Hepatology, Kindai University School of Medicine, Professor)


We aim to develop a method for early diagnosis of chronic hepatitis including NASH by detection of the slight change of fibrous progression based on precious evaluation of the mechanical properties, i.e., viscoelasticity by ultrasound elastography and functional properties such as oxygenation of tissues by photoacoustic technology. Specific research topics are as follows, (1) Improve the precision of tissues viscoelasticity evaluation by modeling the shear wave propagation. (2)Evaluate the characteristics and functional properties of liver tissues by photoacoustic imaging with models of optical absorption and refraction. (3) Apply the method to early and differential diagnosis of liver diseases

Project Design